• survivin (baculoviral IAP repeat-containing protein 5) (21-2

  2019-12-13

  

  Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor survivin (baculoviral IAP repeat-containing protein 5) (21-28) within the GC. The identificatio

• nuclear receptors Herein the interactions of etamicastat nep

  2019-12-13

  

  Herein, the interactions of etamicastat, nepicastat and zamicastat with P-gp and BCRP were evaluated. Although recent investigations have been performed to assess the involvement of P-gp in the nuclear receptors exposure of nepicastat and etamicastat (Loureiro et al., 2015), the contribution of BCRP

• br Acknowledgments Grant support was provided by the

  2019-12-13

  

  Acknowledgments Grant support was provided by the Leading Academic Discipline Projects of Shanghai Municipal Education Commission (J5028) (J50201) to Dr. Mi, the China National Science Foundation Project (81072076) to Dr. Mi, the China National Science Foundation Project (31000349) to Dr. Shen, a

• The absence of the LIG gene in yeasts

  2019-12-13

  

  The absence of the LIG3 gene in yeasts has prevented the use of genetically tractable lower eukaryotes, such as Saccharomyces cerevisiae and Schizosaccharomyces pombe, as models to gain insights into the cellular functions of and interplay between the DNA ligases encoded by the LIG1, LIG3 and LIG4 g

• We used two different VSMCs cell lines KSB and

  2019-12-13

  

  We used two different VSMCs cell lines, KSB and CSD (isolated from two different thoracic aortas). Rat aortic VSMCs were isolated from medial segments from thoracic rate 81 5 from Wistar-Kyoto rats (six to eight weeks old, Charles River Wiga GmbH) and cultured over several passages as described . Q

• HvPap a member of the cathepsin F like

  2019-12-13

  

  HvPap-1, a member of the cathepsin F-like family, was identified in germinating barley seeds (Sreenivasulu et al., 2008). This enzyme participates in the mobilization of stored proteins (mainly hordeins) during the last phase of grain germination, and its activity is modulated by a propeptide or/and

• br Materials and methods br Results and discussion br Conclu

  2019-12-13

  

  Materials and methods Results and discussion Conclusions In this study, we have investigated the possibility that hierarchical phosphorylation by CK2 may play a role in cellular signal transduction. Hierarchical phosphorylation by CK2 requires multiple consensus determinants with specific s

• Case report The patient was referred to the oral and

  2019-12-13

  

  Case report The patient was referred to the oral and maxillofacial department at the authors’ institution for further evaluation and treatment. The patient underwent tumor resection with left hemi-mandibulectomy with wide bony margins (Fig. 1A), and mandible reconstruction with fibula free flap and

• The human serotonin hydroxytryptamine HT

  2019-12-12

  

  The human serotonin (5-hydroxytryptamine; 5-HT) receptor family consists of 14 receptor subtypes to date, which are primarily G protein-coupled receptors (GPCRs) with 5-HT3 being the sole ligand-gated ion channel (Alexander et al., 2017). These receptors are widely distributed in the central and per

• Both meiotic COs and NCOs

  2019-12-12

  

  Both meiotic COs and NCOs require DNA synthesis, current data from sequencing also suggest that COs require more DNA synthesis than NCO 63., 64., 65.. However, analysis of the role of DNA synthesis in NCOs remains relatively uncharacterized. Emerging evidence points to a role for either Polδ or Polε

• Primary human GBM neurospheres expressed high levels of

  2019-12-12

  

  Primary human GBM neurospheres expressed high levels of the metabolic enzyme fatty acyl-CoA synthetase VL3 (ACSVL3) that were associated with CSCs self-renewal and tumorigenic capacity. ACSVL3 knockdown significantly decreased ALDH levels, indicating its contribution to cell metabolism and maintenan

• Mifepristone Introduction The term myeloproliferative disord

  2019-12-12

  

  Introduction The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myelopro

• br Methods and materials br

  2019-12-12

  

  Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic DTP3 to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that is expressed in many ti

• br Results and Discussion br Conclusion

  2019-12-12

  

  Results and Discussion Conclusion What we have shown here is that highly specific antagonist can be a very useful tool, can mimic gene KO experiments or even further dissect receptor function. We just took ETA antagonist as an example and found that ETA mediates physiological closure of DA whi

• Not all of the biological activities exhibited by progestoge

  2019-12-12

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the herpes simplex virus is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to

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