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Alexithymia is related to abnormal emotional processing Spec
2020-08-03
Alexithymia is related to abnormal emotional processing. Specifically, the difficulty in identifying one’s own emotions partly attributes to deficits in emotion processing (da Silva et al., 2017; Zamariola et al., 2018). When individuals showed deficits in emotional awareness, emotional self-regulat
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Potency efficacy and biocharacter define the concentrations
2020-08-03
Potency, efficacy and biocharacter define the concentrations of progestogens required to cause or inhibit particular biological or physiological effects, the upper and lower limits of those responses, as well as how these change over a range of concentrations or doses [40]. These parameters are thus
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We previously reported that the changes in the expression le
2020-08-03
We previously reported that the changes in the expression level of DGKδ2 affect C2C12 myogenic differentiation [39]. Proteostasis requires both protein synthesis and degradation. Indeed, protein degradation via the ubiquitin-proteasome and autophagy-lysosome systems is important for skeletal muscle
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br Materials and methods br Results br
2020-08-01
Materials and methods Results Discussion Msn2 and Msn4 mediate transcriptional activation of numerous genes in response to multiple different environmental signals as a central regulator [31]. In this study, we presented compelling evidence that CK2 positively regulates transcriptional acti
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While the LPS and BLM
2020-07-31
While the LPS and BLM models differ in terms of their pathogenetic mechanisms, the initial inflammatory events share common features. In particular, the initial 24–48 h period following instillation of either agent consists of a marked influx of neutrophils into the lung [8], [9]. In the LPS model,
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In regards to regional variation in
2020-07-31
In regards to regional variation in metabolic behavior of adipose tissue, subcutaneous adipose tissue transplantation has been shown to reprogram visceral adipose tissue to have subcutaneous-like phenotypic behavior, whereas visceral-to-subcutaneous transplantation does not promote a more detrimenta
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The cytoplasmic domain of classical cadherins is highly
2020-07-31
The cytoplasmic domain of classical cadherins is highly conserved and can interact with different cytosolic proteins. Typically this domain is associated with catenin family members, including p120 catenin, β-catenin, and α-catenin, which form a cadherin-catenin complex (Fig. 1). The catenin family
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Cyclosporine NEORAL Oral Solution Novartis is an immunosuppr
2020-07-31
Cyclosporine (NEORAL® Oral Solution, Novartis) is an immunosuppressant widely used in organ transplantation and many other clinical conditions [12]. It undergoes extensive hepatic and intestinal biotransformation mainly via the metabolizing enzyme, CYP3A4 [[12], [13], [14], [15]]. Considering the na
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br Cellula http www apexbt com media diy
2020-07-31
Cellular sources of cytokines that trigger and maintain ILC Many studies are now beginning to address the cellular sources and tissue microenvironmental conditions that may imprint ILC identity and trigger their responses during development and in either steady state or pathogenic tissue conditio
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For mounting an effective immune response by
2020-07-31
For mounting an effective immune response by secretion of pro- or anti-inflammatory mediators and phagocytosis of invading pathogens or cellular debris during an infection, deployment of specific subsets of macrophages to the site of inflammation must be temporally and spatially strictly regulated.
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br Results br Discussion LNX
2020-07-31
Results Discussion LNX1 was first identified as a binding partner of Numb and interacts with c-Src in a PDZ-dependent manner, triggering its ubiquitination [18]. Until recently, no structure-based mechanism had been established for the LNX family of proteins. Here, we identified the ubiquitina
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br Experimental br Results and discussion br Conclusion In
2020-07-31
Experimental Results and discussion Conclusion In this endeavour, a simple and cost-effective DNA-templated hydrothermal method was employed for the synthesis of high-performance electrochemical supercapacitive Bi2MoO6 electrode material. The structural properties of the prepared Bi2MoO6 ma
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Although the formation and toxicity of
2020-07-31
Although the formation and toxicity of DPC is theoretically acceptable, it is difficult to evaluate the specific role of DPC and its repair enzyme MGMT in the cytotoxic and mutagenic effects because DPCs are estimated to constitute only 1%–3% of total DNA damage when LY335979 australia are exposed
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TRAM 39 Diacylglycerol kinase was one of the hits identified
2020-07-31
Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a TRAM 39 of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61], [62], [63]. Some of
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On the other hand Ferreira
2020-07-31
On the other hand, Ferreira and co-workers reported that increasing the number of pulse reduces the need for increasing the pulse amplitude for maximal MSC electroporation [19]. Our study showed that when two pulses were applied at 400V, 375μF, the transfection efficiency was increased from 0.006 to
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