• Telomerase action at the telomere is highly regulated

  2024-05-10

  

  Telomerase action at the telomere is highly regulated; it preferentially elongates the shortest telomeres, and recruitment of the enzyme complex to the telomere occurs in mid-S phase of the cell cycle (Bianchi and Shore, 2007, Britt-Compton et al., 2009, Teixeira et al., 2004, Hemann et al., 2001, T

• br Experimental procedures br Results br Discussion Although

  2024-05-10

  

  Experimental procedures Results Discussion Although previous studies have indicated that astrocyte aromatase plays a role in nociceptive processes (O'Brien et al., 2015, Smeester et al., 2016), the mechanisms responsible for the regulation of aromatase and its involvement in nociception rem

• br Material and methods br Results br

  2024-05-10

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential AV-951 for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparaginase is

• HMGN proteins are subject to extensive

  2024-05-10

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to (S)-10-Hydroxycamptothecin mg and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (rev

• br Identification of the croaker mAR cDNA Testosterone T

  2024-05-10

  

  Identification of the croaker mAR cDNA Testosterone (T) was observed to alter steroidogenesis through a nongenomic mechanism (not blocked by the transcription inhibitor, actinomycin D) in Atlantic croaker ovarian tissues (Braun and Thomas, 2003). This action of T was mimicked by T conjugated to B

• topotecan br Introduction Metabolic cues are crucial inputs

  2024-05-10

  

  Introduction Metabolic cues are crucial inputs in dictating acute responses through governing cellular signaling pathways as well as in shaping up long-term transcriptional and epigenetic profiles to control chronic cellular responses (Lu and Thompson, 2012). It has been well documented that meta

• Although AMPK is a negative regulator of

  2024-05-10

  

  Although AMPK is a negative regulator of bioenergetic reprogramming in cancer cells, little is known about the role of AMPK in immunometabolism in sepsis. Our current study indicates that AMPKα dysfunction enhances PKM2-dependent aerobic glycolysis, which results in HMGB1 release in macrophages and

• br Material and methods br Results br Discussion Aminopeptid

  2024-05-10

  

  Material and methods Results Discussion Aminopeptidase N is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN expression is dysregulated in inflammatory diseases as well as in solid and hematologic tumors

• br Conclusion br Introduction The identification of

  2024-05-10

  

  Conclusion Introduction The identification of Alzheimer's disease (AD) biomarkers and their ability to measure pathology antemortem has led to a fundamental reconsideration of the pathogenesis of AD. The importance of biomarkers was already reflected in revised diagnostic criteria proposed by

• We also demonstrate that PACAP treatment dose dependently di

  2024-05-09

  

  We also demonstrate that PACAP treatment dose-dependently disrupts performance in the 5CSRTT, suggestive of attentional deficits, another core feature of mood and anxiety disorders. Treatment with PACAP (.5–1.0 µg) decreased the percentage of correct responses, increased the percentage of trials in

• Active SI behavior was dose dependently affected by PACAP tr

  2024-05-09

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p sb chemical 1 week later (F3,20 = 8.93, p a main effect of treatment (F3,20 = 4.29, p hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depressio

• br Discussion Here we focused on seven

  2024-05-09

  

  Discussion Here, we focused on seven plant alkaloids extracted from yokukansan. These alkaloids individually inhibited 5-HT-mediated 5-HT3A and 5-HT3AB receptor currents weakly. Simultaneous administration of these alkaloids, however, inhibited the 5-HT3A and 5-HT3AB receptor currents strongly. T

• AXL is a member of

  2024-05-09

  

  AXL is a member of the TAM (Tyro3, Axl, Mer) family of receptor tyrosine kinases (RTKs) [4]. Elevated AXL expression could promote oncogenic processes such as cell growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT), which substantially contribute to tumor progression and poo

• br Materials and methods br

  2024-05-09

  

  Materials and methods Results Discussion CUs, which have been used as traditional medicine for thousands of years in East Asian countries, have the potential to be used for cancer chemoprevention and chemotherapy [17], [18], [19], [20]. CuB is one of the most promising agents as it is repor

• br Material and methods br Results br Discussion Asparagine

  2024-05-09

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential phenethyl mg for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparagina

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