• A rational approach for the

  2024-03-18

  

  A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a

• Elevated expression of Aurora A and B frequently

  2024-03-18

  

  Elevated expression of Aurora-A and -B frequently detected in a wide variety of human cancers strongly indicate that high expression of these kinases play roles in the development of cancer associated phenotypes. While Aurora-A has been shown to function as an oncogene when over expressed in mammali

• In considering the roles of these enzymes in

  2024-03-18

  

  In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty tipiracil synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a surprisi

• Since immunoassays cannot specifically quantify each apelin

  2024-03-18

  

  Since immunoassays cannot specifically quantify each apelin peptide, a more reliable approach, mass spectrometry (MS) has been used recently to quantify and characterize apelin fragments in plasma. Using this technology, Zhen et al. showed that [Pyr-1]-apelin-13 was the major apelin form present in

• Although the earlier studies focused on the

  2024-03-18

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic 15-deoxy-Δ-12,14-Prostaglandin J2 receptor and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerou

• Some of previous immunohistochemical studies have compared

  2024-03-18

  

  Some of previous immunohistochemical studies have compared the levels of AR expression in low-grade versus high-grade and/or non-muscle-invasive versus muscle-invasive tumors. There was a significant or marginal decrease (Boorjian et al., 2004, Miyamoto et al., 2012b, Rau et al., 2011, Shyr et al.,

• Consistent with the in vitro results memantine ameliorated A

  2024-03-18

  

  Consistent with the in vitro results, memantine ameliorated Aβ-induced cytotoxicity in rat primary cortical cultures. Studies reported that memantine protected neurons against the damage caused by aggregated Aβ40 or Aβ42 oligomers in vivo[26], [27]. These results suggest that, in addition to its neu

• The mechanisms that control Ahr transcription

  2024-03-18

  

  The mechanisms that control Ahr transcription are poorly understood, especially when considering cell type-specific regulation. A recent report suggested that the Ahr transcription might be directly promoted by RORγt [retinoic 6-Bnz-cAMP sodium salt mg receptor (RAR)-related orphan receptor γt] bas

• NSC 14613 The obtained results indicate that even

  2024-03-18

  

  The obtained results indicate that even when the impairment of the same forms of memory are present, amnesia can develop in different ways. Impairment of memory reconsolidation in the conditioned food aversion model through both the serotonin receptor antagonist and the antagonist of NMDA glutamate

• Although ASD is considered one of

  2024-03-16

  

  Although ASD is considered one of the most heritable neurodevelopmental disorders (El-Fishawy & State, 2010; Geschwind, 2011) and majority of the research on ASD has focused on the genetics of the disorders (Autism Genome Project, C, 2007; Buxbaum & Hof, 2011), single causative gene anomalies accoun

• br Experimental section br Results and discussion br

  2024-03-16

  

  Experimental section Results and discussion Conclusion Acknowledgements This work was financially supported by Recruitment Program of Global Experts, and the Director Foundation of XTIPC, CAS, Grant No. 2015RC011. This work was also financially supported by Natural Science Foundation of

• In an insightful essay Heryanto writes that

  2024-03-16

  

  In an insightful essay, Heryanto (1990, 40) writes that language is “a phenomenon expressing the particular history of a society” that did not exist in many parts of the world. “Language is not a universal category or cultural activity. Though it may sound odd, not all people have a language in the

• We demonstrate a role for low oxygen to regulate ATX

  2024-03-16

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 Decoquinate and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA leve

• br Aurora kinases br Wnt signaling pathway The signal

  2024-03-16

  

  Aurora kinases Wnt signaling pathway The signal transduction pathway of Wnt/β-catenin signaling pathway plays an important role in embryogenesis to control cell differentiation and tumorigenesis [39]. A recent report indicates that 90% of colorectal cancer occur due to the activation of the Wn

• Consistent with a damaging role for increased LOX activity

  2024-03-16

  

  Consistent with a damaging role for increased 12/15-LOX activity in stroke, systemic administration of the 12/15-LOX inhibitor, LB1, 2 h after permanent focal cerebral ischemia significantly reduced infarct size 24 h after the ischemia, and the treatment group demonstrated improved behavioral and he

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