• All Zirconia slices were subjected

  2018-10-25

  

  All 60 Zirconia slices were subjected to artificial accelerated aging using autoclave [14] at 134 °c, 0.2 MPa for 5 h according to ISO standards 13356. Using the same intraoral spectrophotometer the values of CIELab coordinates from each specimen were recorded and translucency parameter (TP) was ca

• Torin1 br H AZ histone exchange H AZ is incorporated within

  2018-10-24

  

  H2AZ histone exchange H2AZ is incorporated within nucleosomes via ATP-dependent activities. The complexes mediating H2AZ-H2A exchanges are well characterized in Saccharomyces cerevisiae and include the Swr1-containing SWR complex (SWR-C). The mammalian orthologue of Swr1 is SRCAP. Both complexes

• br Materials and methods br Results br Discussion

  2018-10-24

  

  Materials and methods Results Discussion The use of hNPCs for disease modeling, drug screening, or cell therapies requires the development of efficacious and cost-effective defined substrates for their expansion and neuronal differentiation. In this study, we employed an unbiased, high-thro

• Despite these achievements in iNSC technology little is

  2018-10-24

  

  Despite these achievements in iNSC technology, little is known on how cellular identities of iNSCs differ from those of NSCs in comparison to pluripotent stem cell-derived NPCs. For instance, it is currently unknown to what extent neural, metabolic and stress response pathways differ between these n

• AZD-9291 Neural stem cell transplantation is currently inves

  2018-10-24

  

  Neural stem cell transplantation is currently investigated as a treatment for different CNS injuries and disorders. One key challenge for a successful cell therapy is that an inflammatory environment in the diseased CNS might trigger glial differentiation of transplanted NSCs or NPCs (Aboody et al.,

• br Resource table Resource details

  2018-10-24

  

  Resource table. Resource details The gene encoding the complement receptor 1 (CR1) was identified to be a risk gene for Alzheimer\'s disease (AD) in genome-wide association studies (Lambert et al., 2009). Subsequently, we demonstrated that a coding copy number variation (CNV) in CR1 could explai

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments Introduction The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the fields of biology and medicine, providing new avenues for research and regenerative medicine applications. IPSCs a

• The molecular study of regeneration

  2018-10-24

  

  The molecular study of regeneration in animals such as the salamander serves as an important basis for understanding the limited regenerative abilities of other animals. The salamander is the only tetrapod where full cellular reconstitution of a lesioned spinal cord occurs and where the adult limb f

• sphingosine Although previous studies begin to recognize the

  2018-10-24

  

  Although previous studies begin to recognize the potential complex genetic architecture of leukemia, unambiguous longitudinal detection of leukemic clones remains difficult to achieve. Ideally, clones should be prospectively defined by unique labeling of sphingosine before tumor initiation, and det

• To address this need we have developed

  2018-10-24

  

  To address this need, we have developed a functional imaging approach for CSC identification. The stem cell phenotype in embryonic stem stearoyl-coa desaturase (ESCs) is maintained by a central triad of master transcriptional regulators, OCT4, SOX2, and NANOG, which promote stemness by upregulating

• Although GPX is known as a

  2018-10-24

  

  Although GPX2 is known as a gastrointestinal GSH peroxidase, it also is expressed in other tissues (Brigelius-Flohé and Kipp, 2012). Interestingly, its expression level is increased in intestinal crypt stem cells and malignant epithelial cells, suggesting a role in proliferation and self-renewal. It

• To explore the potential mechanism underlying

  2018-10-24

  

  To explore the potential mechanism underlying this interesting phenomenon, we examined the role of mTOR in this process as mTOR is well known for its role in controlling cell growth and metabolism, and more importantly, it is known to crosstalk with GSK3 (Inoki et al., 2006). Indeed, we were able re

• Comparative analysis of transgenic hPAX GFP expression revea

  2018-10-24

  

  Comparative analysis of transgenic hPAX6GFP expression revealed similarities between the retinal organoid system and the mouse retina in vivo. Our analyses indicated a similar sequence of hPAX6GFP+ retinal cell types in mice in vivo, and in mESC- and hESC-derived retinal organoids: progenitors and r

• Reliable cell surface markers in defining hematopoietic cell

  2018-10-24

  

  Reliable cell-surface markers in defining hematopoietic ryanodine with different potential are valuable in assessing well-defined populations for further investigation. Cell-surface markers are of particular significance for hPSC differentiation, as the in vitro system lacks anatomical and morpholo

• For the photoreceptors to function recycling of

  2018-10-24

  

  For the photoreceptors to function, recycling of visual pigments by isomerization and oxidation, from all-trans retinol to 11-cis retinol, and to 11-cis retinal, is essential (Parker and Crouch, 2010). The first essential step of isomerization to form 11-cis retinol is catalyzed by RPE65 in RPE for

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