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ABT263 Muscle Ring Fingers MuRFs comprising TRIM MuRF TRIM M
2019-09-04
Muscle Ring Fingers (MuRFs) comprising TRIM63 (MuRF1), TRIM55 (MuRF2) and TRIM54 (MuRF3) are the most studied TRIMs in the heart. However, with increasing knowledge of E3 ligases and recent advancements in the field, many other TRIMs such as TRIM8, TRIM21, TRIM24, TRIM32, TRIM45, TRIM69 and TRIM72 w
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Cellular immune responses such as phagocytosis and apoptosis
2019-09-04
Cellular immune responses, such as phagocytosis and apoptosis, are very important processes to eradicate the invading pathogens and reduce concomitant host damage. And all of these processes are fine-tuned by the ubiquitin system (Li et al., 2016). Phagocytosis is a major mechanism of cellular immun
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Transcription can also be impaired by lesions
2019-09-04
Transcription can also be impaired by lesions in the template DNA strand, which may lead to stalling of RNA polymerase (RNAP) or to transcriptional mutagenesis, thus producing mutant RNAs and proteins [[3], [4], [5], [6], [7]]. At the same time, RNAP can act as a sensor for DNA lesions, by attractin
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Acanthopanax senticosus Rupr Maxim Harms a nontoxic herb bel
2019-09-04
Acanthopanax senticosus (Rupr. & Maxim.) Harms, a nontoxic herb belongs to the family of Araliaceae, which found in Northeast Asia. A. senticosus traditionally used as a tonic to treat rheumatism, diabetes, and hepatitis [7]. Previous phytochemical and biological investigations found its roots and s
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br Materials and methods br Results br Discussion
2019-09-04
Materials and methods Results Discussion Cysteine proteases are upregulated under oxidative stress and play an important role in the preservation of cellular metabolism (Usui et al., 2007). Cysteine proteases are also important under abiotic stresses for plants to degrade proteins denatured
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ARA metabolites which are produced
2019-09-04
ARA metabolites, which are produced through cytochrome P450 (CYP450) enzymes influence cardiovascular homeostasis. Human CYP4A11 and CYP1A2 metabolize ARA to 20-hydroxyecostearonic iap apoptosis (20-HETE) [11], which is a vasoconstrictor [12], platelet activator [13] and naturetic in the kidney [14]
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br Conclusion br Acknowledgements This work is supported
2019-09-04
Conclusion Acknowledgements This work is supported by the National Natural Science Foundation of China (41806151, 41706144), the National Natural Science Foundation of China (31330082). We would like to thanks the support of young science and technology talents training fund of South China Agr
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Recent data obtained with etifoxine suggest that facilitatio
2019-09-04
Recent data obtained with etifoxine suggest that facilitation of GABAergic inhibition may be also associated with an indirect mechanism implying activation of the peripheral benzodiazepine receptor with a subsequent increase in neurosteroid production (Schlichter et al., 2000, Verleye et al., 2005).
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LY2584702 NPC L NPC Niemann Pick C like
2019-09-04
NPC1L1 (NPC1 [Niemann-Pick C-like-1]-like intracellular cholesterol transporter) is the rate-limiting transmembrane transporter for cholesterol LY2584702 from the intestinal lumen, and it mediates the absorption of both dietary and biliary cholesterol., , NPC1L1 is the target of the cholesterol-lowe
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In modern science and technology many optimization
2019-09-04
In modern science and technology, many optimization problems need to be solved in real time, while these classical methods cannot render real-time solutions to these optimization problems, especially large-scale problems. As a new metaheuristic, particle swarm optimization (PSO) [18], [19] has prove
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br Experimental br Results and discussion On the basis
2019-09-04
Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it Solithromycin is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the conve
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The recombinant Scl collagen system has
2019-09-03
The recombinant Scl2 collagen system has shown capability as a biomaterial as well because of its adaptability and scalability. Scl2 was functionalized to crosslink into a hydrogel without disrupting its triple helix [130]. The Scl2–hydrogel crosslinking also did not disrupt cell adhesion and integr
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br Introduction The allergic response is a complex
2019-09-03
Introduction The allergic response is a complex process involving the interaction of several mediators; among these, cysteinyl leukotrienes (CysLTs) represent one of the most important actors in the pathogenesis of airway allergic diseases such as allergic rhinitis and asthma [1]. Pharmacological
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We next considered the mechanism
2019-09-03
We next considered the mechanism of the hepatospecific decrease in CYP3A exerted by EGCG. We examined the possibility that orally administered EGCG was absorbed from the intestine and directly decreased the CYP3A expression level in the liver. Although the bcl-2 inhibitor rate of orally administere
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In the present study we
2019-09-03
In the present study, we used a new luminescent method to measure CYP activity with Luciferin-ME as a substrate which is used for wide ranges of mammalian CYPs, including CYP1A2, CYP2C8, CYP2C9, CYP2J2, CYP4A11, and CYP4F3B. As a result, no significant modulations of CYP activities in B[a]P exposure
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