br Results br Discussion We examined

2018-10-20

Results Discussion We examined gene expression in human intestinal tissue across the developmental continuum in order to determine maturity of in-vitro-derived HIOs. Using global RNA expression data obtained by RNA-seq, several different analyses demonstrated that the HIO transcriptome closely

br Experimental Procedures br Author Contributions

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Bone marrow stromal cells (BMSCs, also called bone-marrow-derived mesenchymal stromal cells) are heterogeneous populations that likely contain varying levels of tripotent (osteogenic, adipogenic, and chondrogenic [

br Experimental Procedures br Author Contributions

2018-10-20

Experimental Procedures Author Contributions M.C. designed, performed, and analyzed all experiments. S.Y.L. performed MO injections and WISH. W.K. conducted embryo treatments and qPCR. K.A. provided cyp24a1, cyp2r1, and cyp27 plasmids. W.G. provided guidance and edited the manuscript. T.E.N. g

cc-5013 Supplier Introduction Oligodendrocyte progenitor cel

2018-10-20

Introduction Oligodendrocyte progenitor cc-5013 Supplier (OPCs) in the mammalian cerebral cortex have been suggested to originate from the ventral telencephalon (He et al., 2001; Marshall and Goldman, 2002). However, cell fate mapping using Emx1::Cre transgenic mice show that many oligodendrocytes

Since the production of lactic acid seems to be the

2018-10-20

Since the production of lactic Fer-1 seems to be the cause of the genotoxic stress, modifying the culture medium could control its production and its effects. Because hESC do not metabolize carbon sources such as fructose or galactose, which generate less lactate, an option could be to use lower co

Wnt agonist 1 Nishi et al a b have developed a method of

2018-10-20

Nishi et al. (2014a, 2014b) have developed a method of inducing cancer stem-like Wnt agonist 1 (CSCs) through the reprogramming and partial differentiation of the immortalized but otherwise normal MCF10A human mammary epithelial cell line. To experimentally test our computational model of oncometabo

br Results br Discussion The adult kidney has a low

2018-10-20

Results Discussion The adult kidney has a low rate of homeostatic cell cycling; yet, following injury, even one severe enough to cause total renal failure, widespread cell proliferation and functional recovery can occur. The mechanisms responsible for generation of new kidney apoptosis during

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank Abhishek Sinha, Chandan Kadur, James Ankrum, and Mamta Jain for helpful and enlightening discussions. Funding supported by the Indo-US Science and Technology Forum (IUSSTF) to J.M.K. and M.S.I.; JNCASR grant to M.S.I.; an

miRNAs are known to regulate the expression

2018-10-20

miRNAs are known to regulate the expression of multiple targets via binding to 3′ UTR. Our finding that the miR-29 family regulates global DNA methylation and demethylation adds another role to the list of common regulatory roles of miRNAs. The miR-29 family was known to regulate ECM proteins in phy

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Tissue engineering technology has become one of the most promising therapeutic approaches for bone regeneration in bone defects (Zou et al., 2011; Ye et al., 2011; Xiao et al., 2011). As a source of mesenchymal ste

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2018-07-29